Steroids and derivatives
Medchemexpress LLC HY-113313 5mg Medchemexpress, Aldosterone CAS:52-39-1 Purity:>98%
Medchemexpress, HY-113313 5mg Aldosterone CAS:52-39-1 Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Dexamethasone phosphate disodium (Standard) | 2392-39-4 | 99.88% | 100 MG
Dexamethasone phosphate (disodium) (Standard) is the analytical standard of Dexamethasone phosphate (disodium). This product is intended for research and analytical applications. Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium is an orally active Glucocorticoid receptor agonist.
- The compound is the grade of analytical standard, which is the reference standard supplied assay.
- Commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Medchemexpress LLC Dexamethasone phosphate disodium | 2392-39-4 | 99.9% | 5 G
Dexamethasone phosphate disodium is an orally active Glucocorticoid receptor agonist.
- Regulates several transcription factors, including activator protein-1, nuclear factor-AT, and nuclear factor-kB, leading to the activation and repression of key genes involved in the inflammatory response.
- Potently inhibits granulocyte-macrophage colony stimulating factor (GM-CSF) release from A549 cells with EC50 of 2.2 nM.
- Induces transcription of the β2-receptor at 10-100 fold higher concentrations than the inhibition of GM-CSF release (EC50=36 nM).
- Inhibits 3xκB (NF-κB, IκBα, and I-κBβ) with IC50=0.5 nM, which is associated with inhibition of GM-CSF release.
- Efficiently inhibits lipopolysaccharide (LPS)-induced inflammation at a dose of 2x5 mg/kg.
TARGETMOL CHEMICALS INC HYDROCORTISONE ACEPONATE 5MG
Also available in 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. Hydrocortisone aceponate (Hydrocortisone 17-propionate 21-acetate) is an effective topical glucocorticoid used in the form of a cream to treat various skin diseases. purity: 99%
Medchemexpress LLC Hydrocortisone cypionate | 508-99-6 | 486.64 | 1 ML
Hydrocortisone cypionate | 508-99-6 | 486.64 | 1 ML
Selleck Chemical LLC Hydrocortisone acetate
Hydrocortisone Acetate (Cortisol 21-acetate) is the synthetic acetate salt form of hydrocortisone a corticosteroid with anti-inflammatory and immunosuppressive properties
Medchemexpress LLC Dexamethasone (Water Soluble) | 50-02-2 | MFCD00064136 | 98.9% | 1493.5 g/mol | 500 MG
Dexamethasone (Hexadecadrol) Water Soluble is a water-soluble form of Dexamethasone and acts as a glucocorticoid receptor agonist and apoptosis inducer. It is used in experimental animals to construct models of muscle atrophy, hypertension, and depression. This compound can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes, with potential for COVID-19 research.
- Regulates transcription factors like activator protein-1, nuclear factor-AT, and nuclear factor-kB.
- Potently inhibits granulocyte-macrophage colony stimulating factor (GM-CSF) release from A549 cells.
- Used in animal modeling for muscle atrophy, hypertension, and depression.
Apexbio Technology LLC Hydrocortisone(Synonyms: Cortisol, 17-Hydroxycorticosterone, Kendall's Compound F), 10mM (in 1mL DMSO), CAS: 50-23-7.
Hydrocortisone (CAS 50-23-7) is an endogenous glucocorticoid primarily synthesized and secreted by the adrenal cortex It exerts biological effects by binding glucocorticoid receptors altering gene expression involved in metabolic regulation immune response modulation and anti-inflammatory pathways Widely utilized in biomedical research hydrocortisone serves as a standard reference agent for investigating glucocorticoid receptor signaling inflammation models and stress response mechanisms
Medchemexpress LLC Prednisone acetate | 125-10-0 | 99.9% | 1 ML
Prednisone acetate is a glucocorticoid and an orally active Notch inhibitor. It exhibits anti-inflammatory activity and can enhance the immune response. For research use only; not sold to patients.
- Orally active Notch inhibitor.
- Anti-inflammatory activity.
- Can enhance the immune response.
- Reduces ocular and peripheral inflammatory responses.
- Restores Th1/Th2 and Th17/Treg immune homeostasis through orchestrating the Notch signaling pathway.
Medchemexpress LLC Hydrocortisone hemisuccinate sodium | 125-04-2 | 99.7% | 25 MG
Hydrocortisone hemisuccinate sodium is an orally active physiological glucocorticoid. It inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. It can be used for the research of ulcerative colitis (UC).
- Orally active physiological glucocorticoid
- Inhibits proinflammatory cytokine activity
- Potential for research in ulcerative colitis (UC)
Apexbio Technology LLC Dexamethasone (DHAP) 50-02-2 10mM (in 1mL DMSO)
Dexamethasone (DHAP) is a synthetic glucocorticoid commonly utilized in biomedical research due to its potent anti-inflammatory function and immunomodulatory effects It exerts its mechanism through glucocorticoid receptor-mediated transcriptional modulation resulting in reduced transcriptional activity of NF- B signaling pathways in dendritic cells (DC) thus inhibiting DC maturation and activation This compound is frequently employed in experiments investigating immune regulation inflammation and cell differentiation processes including induction of differentiation in human mesenchymal stem cells (MSCs) Additionally dexamethasone is used in cancer cell biology research as it promotes autophagy in acute lymphoblastic leukemia-derived cell lines Reported IC50 values for dexamethasone-mediated inhibition of cellular inflammation responses typically range from 2 50 nM depending on specific cellular models and experimental conditions
Sigma Aldrich Fine Chemicals Biosciences Prednisolone >=99% | 50-24-8 | MFCD00003649 | 10G
Prednisolone >=99% | Purity: >=99% | Mol Wt: 360.44 | 50-24-8 | MFCD00003649 | 10G
Cayman Chemical Dexamethasone Phosphate sodi
A glucocorticoid; reduces LPS-induced production of RANTES, TGF-β1, and NO in BV-2 microglia from 1-4 µM; reverses LPS-induced decreases in IL-10 levels in, and inhibits LPS-induced migration of, BV-2 microglia at 4 µM; decreases motor activity and reduces adrenal weight and plasma corticosterone levels in rats when administered in the drinking water at 5 UG/ml; reduces joint swelling in a rat model of collagen-induced arthritis at 1.6 mg/kg per day for a minimum of seven days; reduces pruritis and the clinical lesion score in cats with hypersensitivity dermatitis
Sigma Aldrich Fine Chemicals Biosciences Hydrocortisone 3 O carboxy50MG
Hydrocortisone 3 O carboxy50MG